Global Health Competency Among Advanced Practice Nurses

There is no documentation of global health competency among advanced practice nurses, specifically for Nurse Practitioners in current health related literature. Global health competency is an issue of increasing importance as we face an era of immense globalization, migration, immigration, and widening income gaps. It is widely accepted that lower income status, ethnic and racial disparities place persons at risk for increased morbidity and mortality globally and locally. Additionally, advanced practice nurses, Nurse Practitioners, are increasingly seen as primary care providers for the future aiding rapidly aging and influxes of ethno-diverse cultures. This culminates with already existing high levels of poverty, reliance on government†¦show more content†¦Most physician-driven efforts have been bio-medically focused. One competency assessment by Wilson, et al. was adapted from Medicine for undergraduate nursing by removing treatment and medical diagnoses (2012). In a st udy of 700 undergraduate nursing programs, only 29% offered global health as a separate course outside of standard community health and there are no reports in the literature establishing or documenting global health competence among graduate prepared advanced practice nurses. In another sample of 36 Canadian Association of University Schools of Nursing, only 0.81% of undergraduate students had international experiences and only 2 of 36 institutions had transcultural nursing requirements which limits abilities or competence in assisting diverse populations. We do know utilization of health belief models and transcultural theory have been very effective in implementing health interventions and this has been noted in several studies including the use of social capital in management of disease (Malin, 2014). Cultural mistrust of providers remains amongst low-income persons of minority status who have experienced previous inequity or discrimination has been repeatedly documented and wi ll continue to be a barrier (Benkert,

Social Media s Influence On An Individual s Life

In today’s time social media is major part of everyone’s daily life. For instance, â€Å"people spend over 700 billion minutes per month on Facebook† (Lawrence, 2012). This demonstrates that social media has a major influence on an individual’s life. Not only is social media having an influence over individuals, it is also influencing the way society communicates. For example, communication was once through phone calls or by mail, but now communication is being executed through various form of social media such as, Twitter, Snapchat, Facebook, Tumbler, etc. In addition to social media being used for communication, smartphones are also contributing to this as well. Furthermore, smartphones can be used to access the web when there is no internet.†¦show more content†¦Social media and smartphones allow for better communication between health care employees, peers, and patients because they provide multiple ways for each party to communicate with each other. For healthcare workers to communicate with each other, social media platforms such as, Linkedln, which is a professional site that allows healthcare professionals to network with each other (Miller, 2011). Other sites that healthcare professionals can network through are Facebook and Myspace. Having these social media platforms allows for healthcare workers to connect and share their thoughts with each other. Not only does it help coworkers communicate with each other, it also allows healthcare workers to communicate with patients. For example, patients can access social media platforms for information concerning their condition. By having these social media platforms, it allows for various ways patients can have access to health information. Besides social media providing another form of communication between healthcare workers and patients, it is also a resource tool. Social media allows you to research for information that is needed, similar to professional sites, which c an also be used for networking and as a resource tool. According to Gitelman, Lindsay, and Weaver (2012), these networks can be used to obtain and share information (para. 2). By using these professional sites, the sites can help educate

Festival Presentation Free Essays

string(130) " get yourself a cool refreshment or a chilled pint from any one of the Relentless Boardmasters beach bars found on Fistral beach\." Introduction Slide 1 Background Slide 2 http://www. bluebanana. com/article. We will write a custom essay sample on Festival Presentation or any similar topic only for you Order Now php/191/boardmasters-festival The awesome Relentless Boardmasters festival is one of the most recognised surfing events in the country and has everything you could possibly need for a weekend away. You’ve got music, a surfing event, skating and a whole load more so you’ll never run out of things to do! Where all of the biggest names in surf, BMXing and music come together, Boardmasters is the music event you must check out this summer. Located in one of the most beautiful parts of the country, watch the sun set over the cliff top and get ready for a long night of dancing and buzzing music. The Relentless Boardmasters festival offers an eclectic array of solo artists, rock bands and pop groups, you’ll discover some fresh faces as well as some tracks you’ll want to download the second you return home. You’ll be getting a full five days of sea, sun and a whole load of sand, as well as late night entertainment and world famous sportspeople. With an awesome area designated for festival camping, you won’t want to leave and will be returning year after year. So for fun filled days at the beach packed with entertainment, what more could you want from the Relentless Boardmasters Festival? To get a better feel of the Relentless Boardmasters festival and what it’s about we’ve provided a summary guide of previous years events. We’ve included information on the types of acts and artists that have performed here and other background knowledge on the actual event. So reminisce with us now about some of the most awesome times celebrated at the Relentless Boardmasters festival over the years. History and now Slide 3 http://www. bluebanana. om/article. php/191/boardmasters-festival The Relentless Boardmasters festival was previously known as The Rip Curl Boardmasters Unleashed festival and is known as Europe’s biggest surf, skate and music event. The name was changed in 2009 due to a change in sponsors when the fantastic energy drink company Relentless took over. It has now been running for almost 30 years, celebrating i ts 30th anniversary in August 2011. Since 1981 the Relentless Boardmasters festival has been supplying you with top quality entertainment and sports from the awesome location of Newquay. In 2008 the Relentless Boardmasters festival was headlined by Groove Armada, The Zutons, Audio Bullys, The Pigeon Detectives and Reverend and the Makers. It also contained the introduction and performances of Mystery Jets, Gallows and Ghost of A Thousand on the No Half Measures Stage. Attendees of the 2008 event were lucky enough to experience pleasant, summery weather at the Relentless Boardmasters festival and a line up which had something for everyone. In 2009 the name changed to Relentless Boardmasters and welcomed the first beach session down at Fistral Beach. This year there was a wider range of acts performing at the festival, from The Streets to Master Shortie, there was something for all tastes and styles in 2009. Some of the most well known acts were; Calvin Harris, Roots Manuva, The King Blues, Dan le Sac Vs Scroobius Pip and Noisettes. However, the highlight of the weekend was an awesome performance from headliners Cypress Hill. This year Relentless Boardmasters festival goers were also blessed with perfect weather and the weekend received fantastic reviews. Most recently the 2010 Relentless Boardmasters festival was a huge success. There are now three main stages at the surfing event; Main Stage, Relentless Stage and Vans Off the Wall Music Stage. The beach sessions continue on Fistral Beach on the Wednesday, Thursday and Sunday. Examples of the 2010 highlights include; The Futureheads, Natty, Young Guns, Madina Lake, Chase and Status, Gallows, Plan B, Seasick Steve and Example. The headliners at Relentless Boardmasters festival were Newton Faulkner and Leftfield which both contributed to an awesome review for the entire weekend. There are three main stages at the Relentless Boardmasters festival; Main Stage, Relentless Stage and Vans Off the Wall Music Stage. There are also smaller alternative stages such as; the View Stage, the Residential Dance Tent and the awesome Relentless Beach Sessions held down at Fistral Beach. Main Stage – With huge artists set to play, the Main stage is a playground of entertainment. Having seen bands from the likes of Newton Faulkner, Chase and Status, Calvin Harris, Example and a whole load more, the Main Stage is the place to park your body. Relentless Stage – Perfect for providing you manic fans with music to give your ears the fix they’ve been waiting for, previous bands to have graced the stage include New Young Pony Club, Chase and Status, Crystal Fighters and Dwarves. Vans ‘Off The Wall’ Stage – With a rawer sound blasting from this stage, if you’re in to harder music then this stage is the one to hang out at. Having had We Are The Ocean, Madina Lake, Chickenhawk and Everything Burns stealing the limelight. To check out the line up for the next festival, watch this space or head over to the official festival websites MAP Entertainment at the Relentless Boardmasters festival covers the Watergate and Fistral Beach area, so you can relax knowing you’ll never get bored. Fistral Beach will keep your adrenaline pumping with their surf competition, BMX mini ramp and so much more. Meanwhile, Watergate contains the best music, bars and a variety of fair rides. With such a large scale area, there’s so much to do at the Relentless Boardmasters festival that you won’t know what to do first. The Relentless Boardmasters festival is the place to be if you’re after intense beats, bars to grab a pint and a place to check your facebook account. Take a long walk across the golden beach and soak up some rays if you fancy chilling out. With shops nearby, grab your favourite brand from one of the quirky surf shops that are tucked away. In the heat of the sun get yourself a cool refreshment or a chilled pint from any one of the Relentless Boardmasters beach bars found on Fistral beach. You read "Festival Presentation" in category "Essay examples" Growth of Festival 4 My village attracts over 90,000 unique fans to celebrate the UK’s longest running surf event at Fistral Beach and the music festival at Watergate Bay. In recent years the Boardmasters has truly become ‘Cornwall’s Festival’. Year on year the Boardmasters strives to enhance the event, not only for fans of the festival but also for the town of Newquay and Cornwall County. This is achieved through close workings with the relevant parties including the town and county councils, the emergency services, residents associations and local business. 2012 will once again see application for steady growth across the event in terms of capacity at the music festival site at Watergate Bay and its neighbouring campsite. The increased accommodation should allow a comfortable entry for new visitors to Newquay, bringing with them increased spending and vital repeat tourism. Stakeholders 5 My village Newquay Town Mayor, Andy Hannam said; â€Å"I am pleased to hear that the organisers of the successful Boardmasters event are returning to Newquay for 2012. I personally attended both days of the festival last year enjoying the world class surfing and vast, varied range of music. I was impressed with the way the event was organised and enjoyed by all that took part. Putting on this kind of event is a very difficult balancing act making sure that the people taking part don’t impact in a negative way on the residents living close to the venue. The feedback I received after the event was mainly positive and many lessons are being learned and we will work with the organisers to continue making improvements. I am sure that every effort will be made this year to continue improving the interaction between the Town and the event and Newquay will benefit from the increased visitor numbers we can expect over the weekend. The Boardmasters is a Cornish business and is the busiest week in Newquay’s calendar. As a direct result of the event, visitor spending exceeds ? 5 million throughout the county. The event itself hires over 300 event staff across 20 local businesses as well as using over 30 Cornish contractors and all catering concessions are Cornish based wherever possible. Malcolm Bell, head of Visit Cornwall said; â€Å"Boardmasters is t he high point of the summer season on the North Coast of Cornwall and especially in Newquay. Not only does it contribute almost ? 20million to the local economy but more importantly it delights and thrills tens of thousands of happy visitors. If you love Cornwall, love the beach, love surfing or watching surfing and love great live acts then Newquay and Boardmasters is where you must be this summer. † Management 6 Business Opps 7 Environmental Implications Slide 8 Sustainibility Slide 9 http://www. relentlessenergy. com/features/surfers-against-sewage-at-boardmasters. html SAS at Relentless Energy Drink Boardmasters Surfers Against Sewage’s stand will be present at Relentless Energy Drink Boardmasters, where they will organise daily beach cleans and environmental sessions, and introduce a very intriguing sounding giant board game called Marineopoly. If you want to become a member of SAS, head to their website via their link below. The first 50 people to quote Relentless at sign-up will receive a free and exclusive ACTIVIST t-shirt, as well as all the other member benefits (stickers, a quarterly magazine, posters, a keyring, a 10% discount at their store, exclusive competitions and partner offers and more). If you want to know more, make sure you check out their stand and find out about the excellent work that they do. A very welcome addition to Boardmasters http://myvillage. com/article/relentless-energy-drink-boardmasters-2012 Matthew Owen, director of Cool Earth said; The Boardmasters firmly upholds its eco conscience each year. All waste is recycled wherever possible and twice daily beach cleans ensure nothing is left behind. Further to this, the event supports two strong charities, Surfers against Sewage and Cool Earth. Last year, Boardmasters and Cool Earth protected acres of Peruvian rainforest from deforestation, locking in 8000 tonnes of CO2 and saving the habitat of 17 endangered species. â€Å"Boardmasters put on the best festival of the year and, with Cool Earth, saved 40 acres of rainforest from certain destruction. Let’s do it again this year. Every single act at Boardmasters saved trees in the rainforest with Cool Earth. We’ve never seen a festival so switched on to saving the world. Great acts, great surf and 40 acres of rainforest kept standing. No other festival can compete. † Health and Safety slide 10 Media Coverage Slide 11 Marketing Slide 12 Wrap up Slide 13 Other Stuff Read more: http://www. thisissomerset. co. uk/Licensee-hits-limits-Boardmasters-music/story-18286420-detail/story. html#ixzz2NQJbBnmd Follow us: @thisiscornwall on Twitter | thisiscornwall on Facebook Restrictions on the volume and times music is permitted on a Westcountry beach could threaten the future of one of the region’s top musical and surfing gatherings. Cornwall Council’s licensing committee has decided that music at Newquay’s Fistral Beach has to stop at 11. 30pm and not exceed 65 decibels. The reduction in the time music can be played, which was previously 30 minutes later, at midnight, has come after complaints by some residents who live near the beach. John Lenton, whose company, Fistral Leisure Ltd, was the subject of a licence review by Cornwall Council’s environmental protection team, said the council conditions were now jeopardising the music element of the Boardmasters Festival, Newquay’s biggest event of the year. Mr Lenton holds a licence to stage events at the beach’s car park, including music and a skate competition over three days in August as part of the Boardmasters Festival, this year from August 7 to 11. The committee carried out a review of the Fistral beach car park and ordered that background music from both indoors and outside sources will cease by 11. 30pm. The committee ordered that amplified music will be kept to levels that are acceptable to surrounding businesses. The levels are 65 decibels at one monitoring point and 50 decibels at another. An additional condition is that the licensee will monitor the noise at two locations highlighted on the acoustic report at least once an hour while regulated entertainment is being undertaken. Mr Lenton said four or five people living on Esplanade Road had complained about music, the surfing and skating commentary, and even RNLI beach safety announcements. He holds a licence to stage events at the beach’s car park, including music and a skate competition over three days as part of the Boardmasters Festival. Mr Lenton said: â€Å"When are the council officers going to start backing local businesses? â€Å"Boardmasters is the biggest event of the year and they are trying to push the event out of town. â€Å"It is all over by midnight. It isn’t as if it goes on until 4am. Boardmasters should be thanked, not punished, for holding the event in Newquay – 90 per cent of the town is behind it and businesses rely on it. There will come a time when Boardmasters gets tired of being told off. † Council officers monitored noise levels at properties on Esplanade Road, located at the southern end of Fistral beach, between August 9 and 15 last year. All events take place at the northern end. A report by environmental protection officer Miranda Flannigan states that the team had received numerous complaints from residents and that Fistral Leisure Ltd had been contacted over â€Å"poor management† It added: â€Å"Well-run and well-organised events are welcomed. However, the events relating to the particular licence have had a detrimental effect on residents. † Read more: http://www. thisissomerset. co. uk/Licensee-hits-limits-Boardmasters-music/story-18286420-detail/story. html#ixzz2NQJWqmHX Follow us: @thisiscornwall on Twitter | thisiscornwall on Facebook Read more: http://www. thisissomerset. co. uk/Licensee-hits-limits-Boardmasters-music/story-18286420-detail/story. html#ixzz2NQJOqQgL Follow us: @thisiscornwall on Twitter | thisiscornwall on Facebook ttp://www. newquayvoice. co. uk/news/5/article/3503/ Malcolm Bell, head of tourism at VisitCornwall, says the surf, skate, BMX and music festival generates an annual ? 18. 8 million to the Cornish economy. The statistic was highlighted during his speech at the Headland Hotel ahead of work getting underway to set up this year’s event, which will be held at Fistral Beach between August 10 and 14. The music festival will be staged at Watergate Bay on August 12 and 13, featuring Fatboy Slim, Klaxons, Eliza Doolittle and Stereo MC’s. Mr Bell said: â€Å"In 2009 we did an economic impact of the Boardmasters by talking to tens of thousands of people to find out their total spend. We found there is an ? 18. 8 million impact as a direct result because of the Boardmasters, which equates to 80% going to Newquay and 20% to the rest of Cornwall. â€Å"Cynics would say a lot of people would be coming to Newquay and Cornwall anyway. But if you have the most cynical view I have no hesitation in stating there is a ? 4. 75 million boost coming from people who would never have come anywhere near Newquay and Cornwall if it was not for the Boardmasters. The event is bigger since 2009 so the amount of money generated is even more. â€Å"Cornwall has got an interesting relationship with Newquay. It is love hate. Other parts of Cornwall tend to be negative, which irritates me. â€Å"The Boardmasters bringing in tens of thousands of people shows what Newquay is about. People now want to know when the Boardmasters is on. In terms of promoting Newquay and Cornwall it is brilliant. † Andrew Topham, from organisers Sports Vision said: â€Å"We are celebrating not only 30 years, but this year will be a six star event with a women’s and longboard category. There are 200 surfers taking part and the music event has got Fatboy Slim and the Klaxons headlining. There will also be 150 others acts. † An official warm-up event to get everyone in the mood for the Relentless Boardmasters festival will be staged at Bunters in Truro on Friday, featuring rockers Max Raptor, indie folkers The Travelling Band, plus support from the Suitenoir and singer songwriters Tom Law and Joss White. There will also be lots of Boardmasters giveaways. http://www. cornwall. gov. uk/default. aspx? page=32060 Issued on behalf of the Newquay Safe Partnership As Newquay prepares to welcome enthusiastic festival goers to this years Boardmasters event, Newquay Safe partners continue to work closely together to promote safety and to reiterate that anti social behaviour will not be tolerated. Europe’s only surf, skate and music festival returns to Newquay from 8-12 August with thousands of revellers expected to enjoy the ultimate lifestyle experience against the backdrop of our spectacular coastline and welcoming town. Steve Kessell from VisitNewquay says: â€Å"Boardmasters is a prestigious event in two great locations – Fistral Beach and Watergate Bay. The festivals mix of high level beach based sport and the music festival compliments Newquay’s visitor profile of families and younger visitors seeking a vibrant night time experience. As one of the nations favourite seaside resorts Newquay remains a top holiday choice and events such as Boardmasters add excitement to the holiday menu. † Eve Wooldridge, Manager of the Newquay Business Improvement District, says, â€Å"Boardmasters is a majorly important footfall, accommodation and customer spend driver for Newquay’s overall economy and there is a plethora of day and night-time events that appeal to families, couples and young people alike. All of the involved local businesses are gearing up for a successful week and many run corresponding events or promotions around the Boardmasters. It is helpful to see the joined-up working of the various organisations around Newquay Safe and we look forward to seeing thousands of people enjoying our natural surroundings and making the most of the positive Boardmasters experience. † As part of Newquay Safe’s partnership working, the night time Street Safe portacabin will be operating during Boardmasters. Funded and supported by Newquay Town Council, the portacabin is staffed by Devon and Cornwall Police and South Western Ambulance Service. The Street Safe mobile unit will also be out and about to help people in need anywhere in central Newquay with help, advice, support and assistance available for anyone who needs it; whether it is a lost wallet or bag or a safe place to gather their thoughts. Working closely with Street Safe are the local christian organisation, Street Pastors who support the Police, Ambulance Service, Street Marshals and other partners by helping anyone in need of assistance. Volunteer teams work on Friday nights into the early hours of Saturday morning to help anyone who appears vulnerable or worried. They work closely with the police, ambulance services and Street Safe project by providing a listening voice and pastoral support for people who want it. They are also able to signpost people to other services if they need to. This year the ranks of the Street Pastors have been swelled by extra volunteers coming to Newquay from other parts of the country. Newquay Street Pastor Maria Bunyan says: â€Å"We have been overwhelmed by the support we have received and delighted to welcome volunteers from as far afield as Cheshire who have come to boost our numbers and offer their help. † To keep traffic moving during the Boardmasters event, Headland Road will be closed from Wednesday to Sunday and there will be a park and ride on the A3075 near Trevemper, to take people into town, for the duration of Boardmasters. Town Clerk of Newquay, Andy Curtis confirmed â€Å"Boardmasters is becoming widely recognised as a key part of Newquay’s annual event calendar, bringing many new faces to the Town. Newquay Town Council and Newquay Safe partners work very hard with the organisers each year to ensure the event is developed in a safe and sustainable way; addressing many issues which naturally arise from such a heavy volume of people and vehicular traffic in and around Newquay. We look forwards to this year’s event and welcoming the local and national festival-goers to our town. † Newquay Police will be continuing their No Nonsense campaign to reduce crime and disorder in the popular seaside resort. The robust approach has yielded encouraging results so far this summer leading to a decrease in crime figures and making the resort a better experience for all visitors. How to cite Festival Presentation, Essay examples

Compete Clauses In Employment Contracts

Question: Describe about the Compete Clauses In Employment Contracts. Answer: Introduction Currently, business environments' have become so competitive that the employees either protect or destroy the intellectual property of an enterprise. This has led to the adoptions of various ethical and legal parameters that are grounded in attempts of asset protection. However, the major challenge remains the test for each employee's loyalty which is very critical. The assessment put forward some of the agreements placed by stakeholders to gain confidence among the workers, similarly barring them from disclosure of secrets (National Security, 2010). Such scenario brings about the nondisclosure agreements (NDA) and non-compete clauses. Ethical Issues Regarding NDAs and Non-Compete clauses The two clauses have much more a similar effect despite being separate entities. NDA is a contract in which an employee promises to protect the secret disclosed to him/her for the employment period or in any other transaction regarding the enterprise. The agreement has been widely practiced on the growing technology and the dissemination of information. Violation of this agreement could lead the offender to be sued for the damages (Strauch, 2013). The move is popular among companies in maintaining confidence between existing competitors and the general public fraternity. These include the adoption of things like passwords to operational computers, restricted movements, and confidential documents among others. Employers always find it essential for their employees to adequately fill and sign this clause because of the precious information it entails. Their primary concern is mostly about the attempt of disclose of the particulars to the stiff competitors in the market and ability to utilize the information singly. For instance, prohibition of the website designs, product formulations, or having copyrighted software codes. A non-compete agreement is also a tool for employment contracts just like NDAs that purposely safeguards the business trade secrets. It provides restriction for workers not to be involved in a similar activity in a competitor's firm. Breach of this clause could lead to a court order to stop the indulgence and capable of suing both the employee and the enterprise itself (SPIE, 2012). Protection of Trade Secrets Enterprise trade secret can either be a formula, finance detail, market pattern, device, new products, business plan, and any other valuable in the company, which is the greatest task for a nondisclosure agreement. Secrets are given protection in conditions that the stakeholders have taken necessary precautions to put it secret. And in return, it results to their advantage in the markets. Due to this characteristic in enterprises, this clause is responsible for withholding information from the public domain (Hanson et al., 2010). Resolutions in Violation of Agreements By stakeholder's perspective, noncompetitive clause works best compared to the NDAs concerning trade secrets protection. It is hard to enforce the non-disclosure clauses in a court of law, where one will have to prove what an employee has or is about to disclosed. Therefore, it becomes easier to handle the two appropriately ethically means rather than applying the legal actions that are limited. The law further cannot punish someone's fair discovery that could be legal or illegal that discloses the trade secrecy. To the employees, a non-compete agreement may limit their civil rights and freedom of earn a living at a given place within your abilities. The move will make the clause be under looked by the court for the worker irrespective of the associated terms provided by the organization giving credit to the observation of ethics in resolution rather than enterprise laws (Oswald, 2012). Change of work environments and subsequent shifts in the loyalty of employees have elevated the le vels of breaching contracts. Therefore, paying more attention to their loyalties as equipment for trade secret protecting is of advantage to the employer. Such a move will regain confidence and in turn uplifts the performances, while minimizing risks of the spread of valuable information amongst competitors. Ethical Obligations Significant challenges are posed to stakeholders considering the rate of information distribution and duplication together with the rise in technology. The enterprise has various obligations to catch up on the trends and emerging issues. The workers must be informed of the importance of trade secrets and abide by the existing policies that should be kept in a program (Fanimokun et al., 2012). The stakeholders are conditioned to execute whoever needs to know what kind of policy carefully. The public domain must be restricted to the building or departments that harbor the trade secrets, which can be achieved through the application of technological and physical restrictions. There must be signed clauses between the outsiders and the employees who have got access to the in-house dealings for cases of violation. There should always be a psychological contract between the employer and his or her employees. Such a move gives the stakeholders concern over each one's contribution. The organization should continuously focus on the importance of the trade secrets. In so doing, he or she should monitor the progress of employees carefully. However, there should be limitations to their privacy, since too much of it can tamper with their loyalty. The relation existing between the employer and his employees should observe perpetual respect and understanding. There should be a free, fair and equal opportunity for all employees regardless of their positions. In cases of termination of an employee, an interview is essential. It is when the employer reminds the worker of the obligations regarding post-employment (Stevens, 2011). Such an undertaking is meant to maintain confidentiality and the consequences that one is likely to face in the breaching them. Guidance from the Australian Computer Science on Code of Ethics With regards to the code of ethics on Australian Computer Society, it is required of each and every member of dignity, honor, and display efficient professionalism. This also goes hand-in-hand with patriotism as expected of an employee by the employer (ACS, 2014). The professionalism code entails six ethical values that must be followed by the members just as per the case of NDAs that are signed in an employment contract. The ACS requirements focus on the members to give out the best of themselves, through the provision of quality services that maintains their credibility. This implies to the protection of trade secrets in so as to be unique in the market in NDAs. The ACS code of ethics strives to uplift that are affected by the work of its members which applies similarly to the stakeholders and their potential clients or customers. At the same time, their work will be diligent and competent as per the expectations of the stakeholders. As implicated in NDAs. The ethics hold that the public interest is very primary and is placed before member's private, enterprise or departmental interests. Members are expected, to be honest during skill representation of services and products, learned skills or gained knowledge. The level of professionalism should also be advanced (ACS, 2014). Also, it maintains integrity among colleagues and the society as a whole. This applies to non-compete clauses. Conclusion To conclude, strong psychological loyalties should be established amongst employees of an enterprise. This will give a better opportunity of monitoring its non-disclosure agreements and non-compete clauses that increase efficiency and protect company's trade secrets. Also, one should sign an employment contract that will impair his or her abilities to earn a living. References Australian Computer Society, 2014. Data Assets: Code of Ethics. The Australian Computer Society, Australia. Fanimokun, A. O., Castrogiovanni, G., and Peterson, M. F., 2012. Developing high-tech ventures: Entrepreneurs, advisors, and the use of non-disclosure agreements (NDAs), Journal of Small Business Entrepreneurship, 25(1), pp. 103119. Doi: 10.1080/08276331.2012.10593562 Stevens, L. K., 2011. Non-compete and Non-disclosure covenants: Commonly used boilerplate can impede enforcement, The Journal of Private Equity, p 7. Doi: 10.3905/jpe.2011.201.1.013 Hanson, M. J.,Thompson, J. R., and Dahlgren, J. J., 2010. Overview of Confidentiality Agreements. Labor and Employment Practice Group Non-Competition. LexMundi Publications Ltd. Network Security, 2010. Disclosure and non-disclosure, Network Security, 2010(7), pp. 1920. Doi: 10.1016/s1353-4858(10)70096-9 Oswald, R. S., 2012. The evolving status of non-compete agreements, Compensation and Benefits Review, 44(6), pp. 336 339. Doi: 10.1177/0886368712471592 SPIE, 2012. Non-compete agreements create career detours, SPIE Professional. Doi: 10.1117/2.4201201.04 Strauch, B., 2013. Cases of note -- trade secrets -- Nondisclosure agreements -- non-compete clauses, Against the Grain, 21(5). Doi: 10.7771/2380-176x.2661

Discovery to Debacle Essay Example

Discovery to Debacle Essay Introduction: The outgrowth of the monoclonal antibodies as regulative T cell activators raised a great ardor among research workers to develop them as potent go-betweens for immunotherapy. Although many of these monoclonal antibodies have been marketed for the intervention of assorted diseases [ 1 ] ( Bhogal, 2007 ) , some of them were unable to make this finish due to their discontinuance in the clinical phases. One such model theoretical account is TGN1412. TGN1412 is an IgG4 type of monoclonal antibody which acts as superagonist for CD28, a co-stimulatory receptor required for T-cell activation. Since TGN1412 activates the T cell without anterior activation of the T cell antigen ( TCR ) receptor it was designated as a superagonist [ 2 ] ( Bhogal, 2006 ) . However, the vision of using TGN1412 as an anti-inflammatory agent was crashed when it failed in the first measure of the clinical surveies. The stage 1 clinical test of this promising drug emerged to be a catastrophe taking to dangerous effects in the voluntaries. This reappraisal focuses on the find, presymptomatic development and ethical concerns related to the drug and the possible mistakes made during the period from its find to the ruin. All the above factors had a cascading consequence and contributed greatly to the drug s failure. This fiasco of TGN1412 demands the important change in the current drug testing form for the advancement of the hereafter development of drugs. Development: -To promote the activation of immunosuppressive regulative T-cells, TeGenero, a German Pharmaceutical company developed TGN1412, a wholly humanized monoclonal antibody by protein technology of the non-human species generated antibody ( mice antibody ) to obtain belongingss specific to worlds. Protein technology involved the transportation of the complementary determining parts of a mouse anti-human CD28 ( 5.11.A1 ) antibody into human antibody concatenation proteins derived from Chinese hamster ovary ( CHO ) cells [ 1 ] ( Bhogal, 2007 ) . Autoreactive T-cells doing redness and autoimmunity against certain cells and organic structure tissues are kept in changeless cheque by regulative T cells. Normal T cell activation requires both the T cell receptor and CD28, a receptor protein on surface of T cells for its proliferation and activation [ 3 ] ( Vitetta, 2006 ) . Harmonizing to surveies conducted by TeGenero, TGN1412 can trip the T cells of all specificities and release c ytokines by aiming an antigenic determinant of CD28, a extremely conserved part of CD cringle which is exposed on the extracellular surface of T-cell membranes, therefore short-circuiting the demand to T cell receptor specificity. With this hope of stamp downing the immune system by activation of regulative T cells, TGN1412 was developed as a fresh therapy for autoimmune and inflammatory diseases. In Rheumatoid Arthritis, an autoimmune disease, TGN1412 reduced the degrees of inflammatory go-betweens by activation of the T-cells. B-CLL, most common type of chronic leukaemia is associated with a high white blood cell count and slow accretion of a peculiar type of B-cell. TGN1412 is effectual in intervention of B-CLL by non merely triping and exciting the growing of lymph cells but besides heightening the antigen showing ability of B-cells associated with the B-CLL. [ 2 ] ( Bhogal, 2006 ) We will write a custom essay sample on Discovery to Debacle specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Discovery to Debacle specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Discovery to Debacle specifically for you FOR ONLY $16.38 $13.9/page Hire Writer After complete development, pre-clinical and carnal testing, TeGenero decided to continue with first in human clinical test to measure the safety, tolerability and pharmacokinetics of TGN1412 and supervise its immunogenicity and effects on T cells, B cells and on cytokine degrees in blood serum. For this intent TeGenero recruited Parexel, a separate clinical test unit. The test protocol submitted by Parexel was authorized by Medical wellness regulative bureau ( MHRA ) on 27th January 2006 approved by Medical Ethics commission on 14th February 2006. [ 2 ] ( Bhogal, 2006 ) Phase 1 Clinical test failure: Harmonizing to the test protocol designed, on 13 March 2006, the first group of 6 voluntaries received a dosage of 0.1mg/kg on and was scheduled to have farther escalating doses over three-week period. However, the test turned ruinous and had to be suspended when these voluntaries developed cytokine release syndrome with an unmanageable addition in tissue cytokine concentrations finally taking to multiple organ failure. [ 4 ] ( Schraven, 2008 ) Preclinical: The probe conducted by MHRA and the European governments after the clinical test stated that there were no mistakes in fabrication, preparation and no marks of taint in the batch TGN1412 administered to the voluntaries [ 4 ] ( Schraven,2008 ) . With the purpose of forestalling such fatal events in future, the expert groups were recruited by Secretary of the province for wellness to look into the mistakes taking to failure of the test. The presymptomatic surveies with regard to the species choice, invitro and exvivo testing, appropriate dose choice and carnal surveies were points subjected to re-examination. In-vitro testing: Sing the species choice, non human Primatess are most frequently considered for the presymptomatic testing due to their close familial and pharmacological similarity to worlds. In instance of TGN1412, Rhesus macaques and the cynomolgus monkeys were used as the theoretical account for surveies on the footing that the 6 amino acid epitope on the C D loop of CD28 to which the drug appears to adhere is wholly similar and conserved in both the macaques and the worlds. [ 5 ] ( Stebbings, 2009 ) After careful designing of the TGN1412 based on the conserved sequence of the non-human Primatess, it could place the recombinant human cells showing CD28 with high adhering affinity. Specificity of TGN1412 for CD28 was confirmed with adhering surveies on the human cells showing CD-28, Cytotoxic T lymphocyte antigen-4 ( CTLA-4 ) and the inducible co-stimulator ( ICOS ) , in which TGN1412 did non expose cross-reactivity with the CTLA-4 and ICOS with the fact that both these proteins have high grade of amino-acid sequence homology with CD28. In order to further synergize the species selectivity, adhering ability of TGN1412 in the human, Macaca mulatta and cynomolgus monkeys and gnawers and marmoset T-cells was evaluated. It was found that nanomolar concentration of TGN1412 could adhere specifically to human and Macaca mulatta and cynomolgus monkeys but non with marmoset and rodent T-Cells due to difference in the antigenic determinant of the marmoset and human CD28. In marmoset species , 2 of the amino acids out of 6 differ as compared to rat in which all 6 amino acids are different, therefore impacting the binding of the TGN1412 to CD28 of these species. All these surveies prompted the research workers to continue with the surveies on the Macaca mulatta and cynomolgus macaques. [ 1 ] [ 2 ] ( Bhogal, 2006, 2007 ) Along with pre-dominant look in human lien, CD28 is besides expressed in the lymphatic, respiratory, connective and female generative tissues. Even though being cognizant of this fact, the cross-reactivity surveies in cynomolgus monkeys were performed with limited tissues non accounting for complete tissue distribution of TGN1412. In add-on to this, cross-reactivity was observed with the respiratory CD28 which was unexplained in the redirect examination of presymptomatic trials since respiratory disfunction was observed in the voluntaries who participated in the test. [ 2 ] ( Bhogal, 2006 ) . Thus it was suggested that executing such surveies with wider assortment of tissues would greatly assist in the hereafter development of immunobiologics. In add-on to binding and the cross responsiveness surveies, invitro trials with human peripheral blood mononuclear cells ( PBMC ) were performed for foretelling the invivo specificity and the species sensitiveness for TGN1412 [ 5 ] ( Stebbings, 2009 ) . Since most maps of the antibodies are mediated by adhering of their Fc part to Fc receptor incorporating cells [ 4 ] ( Schraven,2008 ) , in-vitro trials finding specificity, with Fc immobilized TGN1412, which mimicked the Fc binding were performed in cynomolgus monkeys and adult male, due to high grade of similarity in their sequence homology of the Fc receptor. It displayed that TGN1412 could arouse the response merely when it was immobilized onto a surface, or coupled via immobilized Fc-specific antibody. In contrast to the above consequences, immobilisation of TGN1412 in the cynomolgus monkeys did non demo its action as a superagonist [ 5 ] ( Stebbings, 2009 ) . Alternatively it acts as conventional CD28 agonist necessitating T-cel l receptor and CD28 activation for T cell stimulation and above all that it did non trip the cytokine production as seen in the voluntaries in the clinical tests [ 2 ] ( Bhogal, 2006 ) . All these consequences indicated hapless species choice for the presymptomatic trials. Animal Trials: Pharmacokinetic and toxicological issues have been taken into consideration in correspondence with carnal surveies. Pharmacokinetic appraisals made during the comparative survey of the TGN1412 with its variant TGN1112 in Macaca mulatta macaques, indicated that after their IV disposal, both the drugs were present in the blood serum for 20 yearss, with the peak concentration of the T-cells and no indicant of the increased cytokine degrees. Due to the overestimate of these effects in invitro surveies, 28 twenty-four hours surveies were performed in the cynomolgus monkeys. The half life of TGN1412 in these surveies was found to be 8 yearss with ascertained addition in the expansion of the lymph nodes and enlargement of the CD4+ T-cells. Furthermore, 50mg/kg was set as the no-observed-adverse consequence degree ( NOAEL ) even though these surveies indicated 5mg/kg as an optimum dosage for TGN1412. With respects to the 28 twenty-four hours toxicologic surveies conducted in the cynomolgus monkeys, there was no indicant of the drug related toxicity and half life was similar to the pharmacokinetic trials. All the above consequences supported TeGenero in continuing with the clinical tests in homo for proving the safety and efficaciousness of the drug. [ 2 ] ( Bhogal, 2006 ) Methodological and Ethical concerns: -The calamity of the TGN1412 alerted the field of immunotherapeutics, to non merely meticulously study presymptomatic trials but besides safeguard the ethical regulations associated with each procedure in drug development. Sing the methodological concern, the disposal of appropriate dosage is really important. The dosage of 50mg/kg of TGN1412 for the disposal into the voluntaries was selected on footing of no-observed-adverse consequence degree ( NOAEL ) which was a high dosage [ 5 ] ( Stebbings, 2009 ) . However, the dosage selected should be of optimum concentration, optimum signifies that it should be low plenty to protect the safety of the voluntaries and high plenty to arouse the response for which it is tested. Thus the choice of the dosage should be based on use of all relevant information known about the drug including the freshness, species specificity and mark distribution, in vivo dose response curve and receptor tenancy with regard to concentration. From the invivo dose response curve obtained from the surveies on the Human PBMC, bell shaped dose response curve was obtained with optimal responses between 2-10ug/ml. These consequences stated that the dosage should be selected from the scope of doses falling within this curve and implied the usage of MABEL ( minimal anticipated biological consequence degree ) attack for choosing the safe and optimum dosage for the tests [ 5 ] ( Stebbings, 2009 ) . Second, the design of TGN1412 test required the disposal of the drug to six voluntaries within short clip continuance of two proceedingss. Since monoclonal antibodies have fresh mechanism of action, disposal into fewer voluntaries with sufficient clip intervals is recommended. A better method would be detecting the consequence of such drug in one voluntary before continuing with the test. A good pattern of documenting the medical history of voluntary was non followed in the instance of TGN1412 by the test carry oning grou p, Parexel. [ 6 ] ( Ferguson, 2009 ) Sing the ethical issues, each test performed must be in concurrency with the Helsinki s declarations to safeguard the rights and safety of each take parting voluntary. Conversely all take parting groups including the voluntaries and the research groups must follow the ethical guidelines. The inside informations of the approved survey by the Ethics commission must be given to the voluntaries. Consent signifier must be short, concise and comprehensive and each voluntary should be given adequate clip to analyze and do determination sing take parting in the test. In instance of any inauspicious events, the test groups must describe it instantly to the moralss commission to avoid put on the lining the life of participants. In instance of TGN1412 each voluntary was given a big amount of money as compared to other stage 1 tests. In add-on, the clip given to analyze the long consent signifier was limited [ 6 ] ( Ferguson, 2009 ) . Therefore, attention should be taken that none of the regulat ions are breached under any fortunes. The chief aim of the investigational survey on failure of TGN1412 was to better the drug development procedure and cut down its clinical failure. However, even after this catastrophe in 2006, many of the late developed drugs have undergone failure. Taranabant ( MK-0364 ) was developed by Merck A ; Co. for intervention of fleshiness, which is frequently associated with increased hazard of developing cardiovascular diseases, diabetes and malignant neoplastic disease [ 8 ] . Taranabant is a fresh reverse agonist of cannabinoid-1 receptors ( CB1R ) , which are of import in ordinance of organic structure weight, energy usage and lipid and glucose metamorphosis [ 9 ] ( Pacher, 2009 ) . The thought of cannabinoid exciting appetency was based on utmost hungriness experienced by hemp tobacco users [ 8 ] . This observation led to the birth of Taranabant which stimulates weight loss by adhering to cannabinoid receptors and forestalling their activation. The presymptomatic surveies indicated th at acute disposal of Taranabant inhibited the food-intake and weight addition in dose dependent form, therefore taking to weight loss and lessening in organic structure fats which were non observed in smasher mice deficient in the CB1R cistron. Based on these surveies it was found that merely 30-40 % CB1 receptor tenancy was required to advance weight loss. These consequences from presymptomatic surveies inspired the research workers to continue with clinical tests. The first clinical survey was carried out in 24 healthy voluntaries as random, double-blind and placebo controlled test. This survey was successful as it displayed additive and dose dependent addition in AUC0 and Cmax values, long half life of 38 to 69 hours and mild inauspicious events [ 10 ] ( Addy, 2008 ) . Phase II test carried out for 12 hebdomads in 533 patients confirmed that effectivity of Taranabant in bring oning weight loss as compared to the placebo. Phase III test was initiated in 2400 patients and was inten ded to be continued for 2 old ages. Even after 1 twelvemonth of stage III survey in March 2008, Taranabant was found effectual in cut downing dual sum of weight by dosage of 2mg of drug with combination of exercising and diet. However, in October 2008 it was withdrawn due to GI and CNS side effects associated with it. [ 8 ] ( www.drugdevelopment-technology.com ) . Gastrointestinal side effects associated were chiefly sickness, purging concern, drowsiness abdominal uncomfortableness, and increased intestine motion. Other drug associated symptoms observed were mood alteration, fatigue and increased sudating [ 9 ] ( Addy, 2008 ) . Happening of all these inauspicious events compels the research workers to retreat a specific drug from the clinical test. Many other drugs which appeared to be innovators in development of assorted diseases have faced the failure during their clinical testing continuance either due to their toxic effects in worlds or due to unsatisfactory degree of consequence for intervention of the disease. Flurizan ( tarenflurbil ) , developed by Myriad Pharmaceuticals was intended for the intervention of Alzheimer s disease by selective take downing the Amyloid degrees. However, it was withdrawn from Phase III clinical test since it was found to be unproductive in bettering the cognitive signals and everyday activities in Alzheimer s disease patients. [ 11 ] ( www.drugdevelopment-technology.com ) Decision: Since monoclonal antibodies have evolved to be one of the promising drugs in intervention of countless diseases owing to their novel mechanism, a argus-eyed reappraisal of the presymptomatic surveies before their disposal into worlds is critical. The presymptomatic surveies of the antibody based drugs should be performed in Primatess possessing wholly matched antigenic site with that in worlds. Apart from the detailed the analysis of the presymptomatic consequences and appropriate species choice, it is important to guarantee that these methods are validated. Standardization of these methods will assist in more accurate extrapolation of the similar effects in worlds and prevent such tragic events in future. Besides elaborate analysis of the comparative measurings of the binding affinities should be done for both human antigen and archpriest antigen, to command the unforeseen structural fluctuations of the proteins. If all these stairss were followed in instance of TGN1412, the awful event might hold been predicted and life of the voluntaries would non hold been on the hazard. A valuable lesson was learnt in the field of research that even a little faux pas in any portion of drug development might take to a large blooper and therefore careful hazard analysis and examination of each measure in the drug development in hereafter will greatly heighten the field of drug find, development and cut down the failure of possible drugs. Mentions: [ 1 ] N.Bhogal and R. Combes, Toxicology in Vitro Vol 21:1227-1232, 2007 [ 2 ] N.Bhogal et.al, ATLA 34,225-239, 2006 [ 3 ] E. Vitetta et.al, Perspective Immunology, Vol 313: 308-309, July 2006 [ 4 ] B. Schraven et.al, Immunity Vol 28:591-595, May 2008 [ 5 ] R. Stebbings et. Al, Current Opinion in Biotechnology, Vol 20: 673-677, 2009 [ 6 ] P.R. Ferguson, The SciTech Lawyer, Vol 5 ( 4 ) , 2009 [ 7 ] MJH Kenter and A F Cohen, Lancet, Vol 368:1387-1391, October 2006 [ 8 ] hypertext transfer protocol: //www.drugdevelopment-technology.com/projects/taranabant/ [ 9 ] Pacher et. al. , Arteriosclerosis, Thrombosis A ; Vascular Biology, Vol 29 ( 1 ) :7-9, Jan 2009 [ 10 ] C. Addy, Journal of Clinical Pharmacology, Vol 48: 418-427, 2008 [ 11 ] hypertext transfer protocol: //www.drugdevelopment-technology.com/projects/flurizan/

Do not miss these cities while exploring Europe

Do not miss these cities while exploring Europe The lesser-known European cities which are worth tourist attention Paris, Amsterdam, Copenhagen, Florence, Berlin†¦All these famous cities have become the visiting cards of Europe. However, there are many other European cities which deserve our attention as well. They have a lot of interesting things to offer. These underrated cities are full of hidden cultural and historic treasures. So, it is high time to explore them.   The charming, cobblestone city of Maastricht This Dutch city will definitely impress you with its French and Belgian twists in the architecture, Roman and Spanish ruins, and sophisticated drink and food. It is considered to be one of the oldest cities in the Netherlands. Maastricht is a lively and energetic place with beautiful historic streets and a distinct international spirit. The biggest attractions of Maastricht are the underground tours to the casemates. It would be very interesting to walk through the tunnels and listen to the stories about the life underground. You can also enjoy the stunning Limburg landscapes during a boat ride over the river Meuse. Don`t forget to visit the annual European Fine Art Fair and enjoy the artworks of contemporary and modern artists. The ancient, Arabic-inspired city of Cadiz The Andalusian city of Cadiz is almost entirely surrounded by water. It has no shortage of breathtaking views and tourist attractions. White houses, open plazas, cobblestone streets, wonderful beaches and seafood, and charming old center – all these things will definitely impress every visitor of Cadiz. This city is well known for its fabulous seafood and fish. At El Faro restaurant you can enjoy some delicious local dishes. Don`t forget to take an excursion to Castillo San Sebastian, which is a magnificent historic fortress, linked to the sea by a tidal causeway. Hamburg – a Germany`s Gateway to the World Hamburg is the second largest city in Germany, the biggest port, and the centre of international trade. It is one of Germany`s wealthiest cities. There are a lot of attractions in Hamburg which are really worth your attention. There is always something to marvel at the Fish Market, HafenCity, and Port of Hamburg. You can visit the century-old Speicherstadt, which is the world-largest contiguous warehouse complex. Elbphilarmonie in HafenCity is a new cultural and urban landmark of Hamburg. It is one of the ten best concert halls in the world, where you can enjoy the classical music culture, music of the 21st century and sophisticated light music. The Portugal city of Porto will become your love at first sight Its higgledy-piggledy medieval centre, charismatic locals, divine food and wine, beautiful monuments and bridges, tiles, shopping streets, hipster bars, flowering balconies, baroque churches, and colorful cliffs will definitely leave you breathless. This city looks like it has emerged from the pages of a storybook. The River Douro on the Gaia side and the historic centre of Porto belong to the World Heritage. Don`t miss to visit Casa do Infante, by Riberia, enjoy the great beaches and cafà © terraces at the mouth of the river Douro, explore Porto by night, try a francesinha, which is one of Porto`s specialties, and stroll through the Parque da Cidade, down the seafront. Perugia – the picturesque Umbrian city with rich history Perugia is a substantial town city with good transport links and a number of historical attractions. It is a medieval, hilltop city that rises above the lush vineyard and hills. It is a major center of medieval art and a major producer of chocolates. It is a home of the Eurochocolate Festival and Umbria Jazz Festival. The Saint Peter`s Basilica is one of the most significant and symbolic landmarks of the city. Fontana Maggiore is the main symbol of Perugia. It is a perfect holiday destination with the beauty of the architecture and active leisure active ideas. The charming city of Aarhus has plenty to offer Aarhus is the second-largest city in Denmark, which is full of opportunities for tourists. It is surrounded by beautiful nature. Here you will find wonderful areas for running, walking, and biking. It has several attractions that are renowned internationally. Den Gamle By, ARoS Aarhus Art Museum, Musikhuset Aarhus, Moesgaard Museum, and Tropical Houses at the Botanical Garden are the absolute best attractions in Aarhus. You should definitely visit this city if you are interested in art and architecture.

Political Science - Global Warming Essay Example | Topics and Well Written Essays - 500 words

Political Science - Global Warming - Essay Example The most prevalent of these gases is carbon dioxide. There has always been a natural layer of greenhouse gases in the Earth’s atmosphere, but the present augmentation is widely held to be the result of human activities, primarily the burning of fossil fuels and environmental alterations, especially deforestation. The burning of fossil fuels – coal, oil and natural gas – is mainly done in industrial processes, in energy production, and also in transport. Because fossil fuel consumption is much greater in industrialized and more economically developed countries, North America, Europe and Asia are responsible for over 90% of global fossil fuel output. Deforestation, meanwhile, is most serious in South America, and especially in the Amazon basis. Furthermore, if current trends continue, fossil fuel consumption will continue to increase, especially as countries with large populations, such as India and China with a combined population of over 2 billion, rapidly indust rialize. All of this is causing the temperature of the Earth to increase at a much faster rate than is usual, and perhaps at a rate faster than it has been for thousands of years. The increasing blanket of greenhouse gases traps heat from solar radiation in the Earth’s atmosphere, and as the temperature within becomes higher, water stored as ice in glaciers or the ice caps is melting, causing sea levels to rise.